NanoConjugates

The performance of our NanoConjugates is confirmed by various assays. Some of them are illustrated below.

Signal Intensity and Discrimination

NanoConjugates possess a high antibody class specificity, illustrated for example by the following assay: beads were coated with different Antibody Classes and Subclasses and incubated with Acridinium labelled NanoConjugate. The subsequent luminescence measurement reveals high signals and target specificity.

Moreover, the performance of NanoConjugates in a diagnostic test setup outperforms standard antibody conjugates derived from rabbit. Beads coated with Borrelia burgdorferi derived antigens were incubated with blood serum from a patient with known infection and from a healthy person. Bound antigen specific antibodies were detected with Acridinium labelled standard conjugate or a NanoConjugate. Signal discrimination between positive and negative blood sample (P/N ratio) of the NanoConjugate is multiple times higher than that of a standard antibody conjugate.

Stability

NanoConjugates are proven to be stable for at least 350 days at 4°C. The following assays show the signal intensity of Acridinium labelled NanoConjugates per se as well as its performance in a diagnostic test setup with Borrelia burgdorferi antigen loaded beads and blood serum from an infected patient over time.

Cross Reactivity

Select a NanoConjugate with narrow cross reactivity according to your specific requirements or select one to detect antibodies from
a broader range of species.